Biliary excretion of copper in LEC rat after introduction of copper transporting P-type ATPase, ATP7B

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Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b

Rachel Linz,* Natalie L. Barnes,* Adriana M. Zimnicka, Jack H. Kaplan, Betty Eipper, and Svetlana Lutsenko Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon; Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois; and Department of Neuroscience, University of Connecticut Health Center, Farmington, Conne...

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Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.

Kidneys regulate their copper content more effectively than many other organs in diseases of copper deficiency or excess. We demonstrate that two copper-transporting ATPases, ATP7A and ATP7B, contribute to this regulation. ATP7A is expressed, to a variable degree, throughout the kidney and shows age-dependent intracellular localization. In 2-wk-old mice, ATP7A is located in the vicinity of the ...

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Copper stabilizes the Menkes copper-transporting ATPase (Atp7a) protein expressed in rat intestinal epithelial cells.

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Biliary excretion of copper in Wilson's disease.

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1999

ISSN: 0014-5793

DOI: 10.1016/s0014-5793(99)00319-1